Human activities in space environments still have a negative effect on the astronauts’ health. Therefore, the STAMAS (Smart technology for artificial muscle applications in space) consortium will develop a new type of astronauts’ suit, a “smart-suit”, which will mitigate the pernicious effects of weightlessness and motor inactivity and, thus, maintain the astronauts’ health and physical fitness during and after a space mission. The project will utilise existing terrestrial experience in Shape Memory Alloys (SMA), Electroactive Polymer (EAP) technology and man-machine cooperative control, and build an actuated space exoskeletal suit for usage in a space station. Further research will focus on new concepts of sensing, biofeedback and cardiopulmonary control strategies implemented into the suit. The consortium, led by ARQUIMEA, is a balanced group of SMEs and research institutions that will develop and validate technical components, which will have a strong impact in the space industry, facilitate high-risk and high-impact research and innovation, and reinforce new research alliances.